Clinical Trial

Effects of Minimal-Flow Sevoflurane and Multimodal Analgesia in Head and Neck Cancer Surgery

Unknown Phase 4
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Record status
This record was last updated July 26, 2024 (before its estimated June 2025 completion). Its status may not reflect the trial's current state.
Summary
This study evaluates the anesthetic-sparing and renal protection effects of minimal-flow sevoflurane anesthesia combined with multimodal analgesia using dexmedetomidine, ketamine, and lidocaine in head and neck cancer patients undergoing free flap microvascular surgery. The 2x2 factorial randomized controlled trial aims to compare sevoflurane usage and renal function changes with different fresh gas flow rates and multimodal analgesia.
Protocol Amendment History 1 change
critical Trial status changed: Not Yet Recruiting → Unknown 2026-08-02
Trial Details
NCT Number NCT06521697
Lead Sponsor National Taiwan University Hospital
Conditions Head and Neck Cancer, Anesthesia, Renal Protection, Acute Kidney Injury, Multimodal Analgesia
Enrollment 60 participants
Start Date 2024-08
Primary Completion 2025-06 (estimated)
Study Completion 2025-12 (estimated)
Updated on ClinicalTrials.gov 2024-07-26