Translational Study of MSS, TP53 Mutation and Chromosome Instability Relationship in Endometrial Carcinoma

The objective is to understand the relationship between TP53 mutation, MSS and chromosome instability in endometrial cancer and the effect on clinical prognosis.We will collect a small amount of tumor tissue samples. NGS panel detection and WGD/AS analysis were performed on the tissue. Paracancer tissue was used as a negative control and relevant information in medical records during the operation. Then we will collect clinical diagnosis and disease information through telephone follow-up after the completion of the operation.

NCT Number	NCT06521684
Lead Sponsor	Peking Union Medical College Hospital
Conditions	Endometrial Neoplasms, TP53 Gene Mutation, Chromosomal Instability, Microsatellite Stable Endometrial Carcinoma
Enrollment	110 participants
Start Date	2024-09-01
Primary Completion	2025-06-01 (estimated)
Study Completion	2025-06-01 (estimated)
Updated on ClinicalTrials.gov	2024-07-26