Clinical Trial

Trimethylamine N-oxide Effects of a Pomegranate Supplement Simultaneously With Carnitine (TESSA)

Study acronym: TESSA
Active, Not Recruiting
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Summary
Trimethylamine N-oxide (TMAO) is produced in some individuals whose diets include meat, fish, and dairy.These foods are rich in L-carnitine. L-carnitine is metabolised by the liver and gut microorganisms (bacteria) into TMAO. In the TESSA study, investigators will explore whether pomegranate extract can lower the production of TMAO in healthy men and women. This reduction in TMAO production has been associated with decreasing a person's risk of heart disease.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2024-07-19; most recent amendment 2025-06-13.
Status change: Enrolling by Invitation → Active, Not Recruiting 2025-06-13
Status change: Not Yet Recruiting → Enrolling by Invitation 2024-08-19
Trial Details
NCT Number NCT06518343
Lead Sponsor Quadram Institute Bioscience
Collaborators: Norfolk and Norwich University Hospitals NHS Foundation Trust, Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK)
Conditions Healthy
Enrollment 39 participants
Start Date 2024-08-12
Primary Completion 2027-05-31 (estimated)
Study Completion 2027-05-31 (estimated)
Updated on ClinicalTrials.gov 2025-06-15