China Early Esophageal Cancer Cohort

With the development of endoscopy, more and more patients with superficial esophageal squamous cell carcinoma (ESCC) receive endoscopic resection rather than traditional surgery. However, there is still no complete consensus on the risk factors for lymph node metastasis (LNM) and recurrence of ESCC after endoscopic resection. The existing curative resection criteria are strict to a certain extent, and a considerable number of patients are overtreated according to the current standard of additional treatment. Thus, we aim to conduct a multi-center retrospective and prospective study to construct a large cohort of ESCC based on the previously established multi-center collaborative research network and clinical big data, analyze the risk factors of LNM and recurrence in patients with early esophageal squamous cell carcinoma after ESD, establish an accurate and simple risk prediction model, and evaluate the discrimination efficiency of this model.

NCT Number	NCT06515964
Lead Sponsor	Changhai Hospital Collaborators: Lianshui People's Hospital, The second affiliated hospital of Xuzhou medical university, Nanning Second People's Hospital, Nanchong Central Hospital, Tongliao City Hospital, Yancheng First People's Hospital, The Second Hospital of Hebei Medical University, The Second Affiliated Hospital of Baotou Medical College, Affiliated Hospital of Southwest Medical University, Sichuan Cancer Hospital and Research Institute, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Zhongda Hospital, The First Affiliated Hospital with Nanjing Medical University, West China Hospital, The First Affiliated Hospital of Soochow University, Jiangsu Province Hospital of Traditional Chinese Medicine, Shandong Provincial Hospital, Shanxi Provincial People's Hospital, Henan Provincial People's Hospital, Anyang Cancer Hospital
Conditions	Early Esophageal Cancer
Enrollment	1,000 participants
Start Date	2022-10-01
Primary Completion	2025-10-01 (estimated)
Study Completion	2025-10-01 (estimated)
Updated on ClinicalTrials.gov	2024-07-23