Effect of a Fasting Mimicking Diet on Patients With Multiple Sclerosis (FMDMS)

In the proposed study, investigators will assess the safety and feasibility of cycles of a fasting mimicking diet (FMD) and its effect on Multiple Sclerosis Quality of Life (MSQOL) in relapsing MS (RMS) patients treated with standard disease modifying therapies (FMDMS). To test the primary hypothesis, investigators will compare the composite quality of life score in terms of improvement in disability, fatigue, and cognitive function with the fasting protocol, as compared to a Mediterranean diet (control) group alone. Further, investigators hypothesize that the effects will remain for at least 6-months after the last FMD cycle. The Mediterranean diet (MD) has been chosen as the control diet to minimize baseline dietary differences among patients. It has been trialed for feasibility in Multiple Sclerosis patients and used in a previous human FMD trial for MS patients where a FMD followed by MD was shown to have positive effects on people with MS.

NCT Number	NCT06515782
Lead Sponsor	University of Southern California
Conditions	Multiple Sclerosis
Enrollment	50 participants
Start Date	2023-10-20
Primary Completion	2025-10-20 (estimated)
Study Completion	2025-10-20 (estimated)
Updated on ClinicalTrials.gov	2024-07-23