Establishing Reference Ranges for Fat-Soluble Vitamins in Healthy Chinese Adults

Vitamins are essential micronutrients required for maintaining normal physiological functions and metabolism in humans. Among them, fat-soluble vitamins (FSV) such as vitamins A, D, E, and K are absorbed in the intestines in the presence of fat. Both deficiencies and excesses of these vitamins can affect health. Current global studies on FSVs in healthy populations are often limited to specific types or regions, and comprehensive data on all four FSVs in the healthy Chinese population are lacking. This study aims to fill this gap by collecting and analyzing FSV levels from healthy adults across multiple regions in China, establishing a reference range for clinical evaluation and early disease intervention.

NCT Number	NCT06512688
Lead Sponsor	First Affiliated Hospital of Zhejiang University Collaborators: Huizhou Municipal Central Hospital, Affiliated Hospital of Jiaxing University, Zhejiang Provincial Tongde Hospital, Affiliated Yueqing Hospital of Wenzhou Medical University, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Zhejiang Provincial People's Hospital, First People's Hospital of Hangzhou, Ningbo Medical Center Lihuili Hospital, Lu'an People's Hospital of Anhui Province, Shandong Provincial Hospital, Second Affiliated Hospital of Nanchang University, The First Affiliated Hospital of Nanchang University, Nanfang Hospital, Southern Medical University, The Third Xiangya Hospital of Central South University, Changzhi Medical College, Linfen No.4 People's Hospital, The Second Affiliated Hospital of Chongqing Medical University, Yulin No.2 Hospital, Hanzhong Central Hospital
Conditions	Fat Soluble Vitamin Deficiencies and Disorders
Enrollment	100,000 participants
Start Date	2024-07-03
Primary Completion	2026-06-30 (estimated)
Study Completion	2026-08-02 (estimated)
Updated on ClinicalTrials.gov	2024-07-22