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Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome

Study acronym: EPIHEAR
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 4 months later Jun 30, 2026 → Oct 30, 2026
See other at-risk trials from Gødstrup Hospital

Record History

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  1. Primary completion pushed from Jun 30, 2026 to Oct 30, 2026v4
  2. Primary completion date: Aug 31, 2026 to Jun 30, 2026v3
  3. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Sep 1, 2024 to Feb 1, 2025
    • Study sites: 0 to 1
    • Eligibility criteria revised
    v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this case-control study is to pave the way for new revolutionary treatment measures within hearing loss that could either replace or delay the need for hearing aids. The study focuses on people with Turner syndrome (TS). The aim is to find out if there are specific DNA methylation patterns and/or RNA expression profiles linked to sensorineural hearing loss (SNHL) in people with TS. Additionally, the structure and function of the inner ear in these individuals will be examined to see if there is a connection to their epigenetic profile. The main question it aims to answer is: Does epigenetics constitute a common denominator for some of the unexplained SNHL cases? Turner Syndrome (TS) represents an ideal model for studying epigenetics related to sensorineural hearing loss (SNHL). Participants will undergo the following tests: * Ear examinations * Hearing tests * Balance tests * Blood tests * MRI scans * CBCT (cone-beam computed tomography) scans
Trial Details
NCT Number NCT06507007
Lead Sponsor Gødstrup Hospital
Collaborators: University of Aarhus, Aarhus University Hospital
Conditions
(from sponsor)		 Sensorineural Hearing Loss, Turner Syndrome, Inner Ear Disease
Related terms Hearing Loss, Sensorineural, Labyrinth Diseases, Turner Syndrome
Enrollment 150 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov