HCAPPED I: HCAP-Pcr in Emergency Department

Prospective Observational Study (on Diagnostic Procedure) - Single-Center, Non-Profit. A pilot study will be conducted on a prospective cohort of patients with HCAP (Healthcare-Associated Pneumonia). This study will be conducted on a single arm of patients. No control group or randomization is planned. The use of syndromic molecular panels in pneumonias with risk factors for MDR (multidrug-resistant) pathogens, such as in patients with HCAP, has become common practice. However, the use of this tool is reserved for patients with severe forms of HCAP (PIRO\>2, at least moderate ARDS, and respiratory failure requiring high-flow oxygen during sepsis) (30), and it is not yet standardized by international guidelines. The decision to use this tool or not is currently at the clinician\'s discretion and is usually reserved for the severe forms mentioned above. The study aims to determine if the early use of this tool has a real benefit on the management of antibiotic therapy for these patients in terms of therapeutic changes compared to corporate and international guidelines. Duration of patient enrollment: 1 year. Duration of the study: 1.5 years.

NCT Number	NCT06506617
Lead Sponsor	Azienda Ospedaliero-Universitaria Careggi
Conditions	Pneumonia, Bronchoalveolar Lavage, Antimicrobial Treatment, Sputum
Enrollment	93 participants
Start Date	2024-06-07
Primary Completion	2025-07-07 (estimated)
Study Completion	2026-01-07 (estimated)
Updated on ClinicalTrials.gov	2024-07-17