Rehabilitation Needs for Hematologic Cancer Candidate for Hematopoietic Stem Cell Transplantation or CAR T-Cell Therapy

Hematopoietic Stem Cell Transplantation (HSCT) and CAR T-cell therapy are effective treatments for blood cancers, extending patients lives. However, these treatments can cause side effects like muscle weakness and fatigue. Recent findings suggest these issues can significantly affect patient quality of life during CAR T-cell therapy. Patients undergoing HSCT and CAR T-cell therapy often face frequent infections and strong immune responses, requiring long periods of rest. This worsens their physical condition and impacts their quality of life, muscle strength, and fatigue levels. Minimizing these side effects is crucial to improve the well-being of patients undergoing these advanced treatments. This study aims to assess the physical abilities (main goal) of patients preparing for HSCT or CAR T-cell therapy. It also aims to examine their quality of life and describe the symptoms and complications they may experience. The results will help identify rehabilitation needs for these patients.

NCT Number	NCT06506396
Lead Sponsor	University of Modena and Reggio Emilia Collaborators: Azienda USL Reggio Emilia - IRCCS
Conditions	Stem Cell Transplantation, Immunotherapy, CAR T-Cell Therapy
Enrollment	20 participants
Start Date	2024-08
Primary Completion	2025-05 (estimated)
Study Completion	2025-05 (estimated)
Updated on ClinicalTrials.gov	2024-07-19