A Self-controlled Study of the Effect of Partial Spectral Absence of Visible Light on the Pupil

Previous studies have shown that the spectrum of light influences myopia. LED lights with a partially absent light spectrum increase the risk of myopia progression compared to LEDs with a full spectrum, potentially mediated by the excitability of the parasympathetic nervous system. This study intends to compare pupil size and area, as well as parameters regulated by the autonomic nervous system (such as skin bioelectrical activity and heart rate), between LEDs with a full visible spectrum and LEDs with a partially absent spectrum around 470nm and 730nm. We aim to elucidate the physiological mechanism underlying the effect of light spectrum on pupil changes and myopia.

NCT Number	NCT06501131
Lead Sponsor	Zhongshan Ophthalmic Center, Sun Yat-sen University
Conditions	Full Spectrum
Enrollment	66 participants
Start Date	2024-07-24
Primary Completion	2024-08-31 (estimated)
Study Completion	2024-09-30 (estimated)
Updated on ClinicalTrials.gov	2024-07-15