Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care

This study, which is aimed at comparing the effectiveness of the most frequently used drugs in the first line in primary care for the preventive treatment of migraine (amitriptyline, flunarizine, topiramate and propranolol), is a multicentre, pragmatic, parallel group, open randomised trial. Adults (≥18) candidates for preventive treatment for migraine; those with a frequency of ≥4 monthly migraine days, and who agree to participate in the clinical trial, will be randomised to one of the 4 groups. Sample: 460 patients. The primary outcome will be the reduction in monthly migraine days, comparing amitriptyline, flunarizine and topiramate with propranolol.

NCT Number	NCT06499116
Lead Sponsor	Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina Collaborators: Institut Català de la Salut, Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Conditions	Migraine
Enrollment	460 participants
Start Date	2024-10
Primary Completion	2026-12 (estimated)
Study Completion	2026-12 (estimated)
Updated on ClinicalTrials.gov	2024-07-12