Geranylgeraniol Supplementation in Patients With Mevalonate Kinase Deficiency

Mevalonate kinase deficiency (HyperIgD syndrome, HIDS) is an inborn error of immunity caused by a block in the mevalonate pathway. The subsequent lack of isoprenoids with antiinflammatory properties might contribute to the autoinflammatory nature of the disease. A pilot study aims to verify the safety and efficacy of the dietary supplement Geranylgeraniol, aiming at a mitigation of isoprenoids deficiency caused by the above-mentioned block in the MVK pathway.

NCT Number	NCT06497829
Lead Sponsor	University Hospital, Motol Collaborators: Washington University School of Medicine
Conditions	Mevalonate Kinase Deficiency
Enrollment	6 participants
Start Date	2022-01-25
Primary Completion	2024-12-31 (estimated)
Study Completion	2025-12-31 (estimated)
Updated on ClinicalTrials.gov	2024-07-12