Lemborexant on Improving Sleep Quality Among Hospital Rotating Shift Workers

Shift Work Sleep Disorder (SWSD) are caused by working shifts with a wake-up schedule and sleeping in a way that is different from the natural way of sleeping and avoiding sleep usually results in deviations. of the biological clock (Biological clock), which is an important cause of sleep problems including insomnia, excessive sleepiness or daytime sleepiness these problems was associated cadiovascular events, decrease quality of life and long term working. At the present there are limited information regarding the effectiveness of medications used to promote sleep in shift workers. Lemborexant is specific in binding to orexin type 2, which has a direct effect on sleep. and there are limited biomarkers monitoring from the use of lemborexant including still not found. Which studies have followed depressive symptoms, anxiety symptoms and cognition from a group of people with insomnia, the aim of study to assessment effectiveness of lemborexant on sleep efficiency, quality of life, symptoms of depression, cognition, BDNF, CRP, IL-6 and TNF-alpha levels. of volunteers working on rotating shifts.

NCT Number	NCT06496282
Lead Sponsor	Phramongkutklao College of Medicine and Hospital Collaborators: Silpakorn University
Conditions	Sleep
Enrollment	50 participants
Start Date	2024-08
Primary Completion	2026-05-31 (estimated)
Study Completion	2026-07 (estimated)
Updated on ClinicalTrials.gov	2024-07-11