Clinical Trial

Effect of Pre-dosing With Methylcellulose or Psyllium on Colonic Fermentation of Inulin

Study acronym: COCOA3
Unknown
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Record status
This record was last updated July 30, 2024 (before its estimated March 2025 completion). Its status may not reflect the trial's current state.
Summary
The aim for this pilot study is to test the hypothesis that pre-dosing with gel-forming dietary fibres (methylcellulose or psyllium) will alter the colonic fermentation of a model fermentable dietary fibre (Inulin) when delivered separately, in contrast to our previous trials where gel-forming and fermentable dietary fibres were co-administered. Performance of each gel-forming dietary fibre will be compared to placebo (water) to assess treatment effectiveness.
Protocol Amendment History 1 change
critical Trial status changed: Not Yet Recruiting → Unknown 2026-08-02
Trial Details
NCT Number NCT06494137
Lead Sponsor University of Nottingham
Collaborators: Quadram Institute Bioscience
Conditions Irritable Bowel Syndrome
Enrollment 35 participants
Start Date 2024-10
Primary Completion 2025-03 (estimated)
Study Completion 2025-03 (estimated)
Updated on ClinicalTrials.gov 2024-07-30