Clinical Trial

Spine Unit Modelling Coupled With hIgh Throughput Analysis (SUIT)

Study acronym: SUIT
Unknown
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Record status
This record was last updated July 8, 2024 (before its estimated August 2025 completion). Its status may not reflect the trial's current state.
Summary
Ageing and inflammation represent two main drivers of DDD, a progressive, chronic condition involving vertebral bone, cartilaginous endplate and intervertebral disc. In vitro investigation of the DDD-associated processes on single compartments of the spine unit or ex vivo animal models fail in recapitulating the complex spine pathophysiology or suffer from inter-species differences. Given these premises, a human organotypic model of the spine unit would represent a suitable tool to investigate the DDD-related pathways and to screen promising treatments such as MSC-based therapies.
Protocol Amendment History 1 change
critical Trial status changed: Recruiting → Unknown 2026-08-02
Trial Details
NCT Number NCT06490887
Lead Sponsor I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Conditions Degenerative Disc Disease
Enrollment 20 participants
Start Date 2023-06-28
Primary Completion 2025-08 (estimated)
Study Completion 2025-08 (estimated)
Updated on ClinicalTrials.gov 2024-07-08