German-funded Laparoscopic Approach to Cervical Cancer

The G-LACC trial is a prospective, interventional, multicenter, open-label, randomized and controlled non-inferiority operative trial. The main goal of this clinical trial is to evaluate the non-inferiority of minimally invasive radical hysterectomy in contrast to abdominal radical hysterectomy in patients with early-stage cervical cancer. In the case of SHAPE criteria, surgery may also be performed as minimally invasive or abdominal simple hysterectomy. The primary criterion for assessment is disease-free survival (DFS). As secondary outcomes, overall survival (OS), disease recurrence, quality of life, intra-/postoperative complications, and serious adverse events are recorded for assessment.

NCT Number	NCT06489795
Lead Sponsor	Hannover Medical School Collaborators: German Cancer Aid
Conditions	Cervical Cancer
Enrollment	756 participants
Start Date	2024-07-17
Primary Completion	2033-07 (estimated)
Study Completion	2034-01 (estimated)
Updated on ClinicalTrials.gov	2025-02-03