Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment

Perioperative neurocognitive disorder (PND) is one of the most common postoperative complications among elderly patients. However, the mechanism and targeted intervention of PND remains unclear. Our previous clinical studies demonstrated the association between olfactory impairment and PND. Moreover, our translational studies showed that anesthesia/surgery induced olfactory impairment and caused cognitive impairment in mice and olfactory enrichment could prevent the anesthesia/surgery-induced cognitive impairment. However, there was no clinical investigation to determine whether olfactory enrichment can mitigate PND in elderly patients. Therefore, we propose determining whether olfactory enrichment can prevent and/or treat PND in elderly patients.

NCT Number	NCT06488807
Lead Sponsor	Shanghai 10th People's Hospital Collaborators: National Natural Science Foundation of China
Conditions	Perioperative Neurocognitive Disorder
Enrollment	686 participants
Start Date	2025-04-07
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-05-14