Evaluation of the Standard Catheter-directed Thrombolysis Effectiveness in Intermediate-High-Risk Pulmonary Embolism Patients

A single-center, open-label, randomized comparative study of two treatment strategies in patients with intermediate-high-risk acute pulmonary embolism (PE). Patients will be randomized in a 1:1 ratio to standard anticoagulant therapy or standard catheter-directed thrombolysis (SСDT) with a low dose of alteplase, followed by evaluation of short- and long-term efficacy and safety in each group

NCT Number	NCT06487052
Lead Sponsor	Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Conditions	Pulmonary Embolism Acute
Enrollment	100 participants
Start Date	2024-01-10
Primary Completion	2027-01 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2024-07-05