Clinical Trial

The Efficacy of Watch and Wait Strategy or Surgery After Neoadjuvant Immunotherapy for Locally Advanced Colorectal Cancer With dMMR/MSI-H Guided by MRD Dynamic Monitoring: A Single-center, Open-label, Prospective, Phase II Clinical Trial.

Study acronym: WINDOW
Recruiting
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Record status
This record was last updated June 27, 2024 (before its estimated October 30, 2025 completion). Its status may not reflect the trial's current state.
Summary
This study is a single arm, single center, phase II, prospective clinical study aimed at exploring the effectiveness and safety of watch and wait strategy guided by dynamic minimal disease residual (MRD) monitoring to achieve clinical complete response after neoadjuvant immunotherapy for locally advanced colorectal cancer with deficient mismatch repair/ microsatellite instability-high (dMMR/MSI-H).
Trial Details
NCT Number NCT06477991
Lead Sponsor Yunnan Cancer Hospital
Conditions Clinical Complete Response Rate With Negative MRD
Enrollment 22 participants
Start Date 2023-10-30
Primary Completion 2025-10-30 (estimated)
Study Completion 2026-10-30 (estimated)
Updated on ClinicalTrials.gov 2024-06-27