Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic Insufficiency

This study aims to evaluate if a 6-month course of pancrelipase (CREON) treatment improves symptoms of exocrine pancreatic insufficiency (EPI) after an attack of acute pancreatitis. Diagnosis of EPI is measured by a fecal elastase value of \<200, and patients must have a qualifying symptom burden based on the EPI symptom tracker survey. Blood and stool will be analyzed as part of this study, and other surveys of health status will be used to track improvement of symptoms.

NCT Number	NCT06477159
Lead Sponsor	Ohio State University Collaborators: University of Pittsburgh, University of Illinois at Chicago, University of Southern California, New York University, AbbVie, University of Minnesota
Conditions	Exocrine Pancreatic Insufficiency
Enrollment	30 participants
Start Date	2024-02-01
Primary Completion	2027-09-30 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-10