Study of Preoperative RAdiation Therapy With Concomitant Liposomal Transcrocetin (L-TC) in Soft tISsue Sarcomas

This is phase II randomized, multicenter study of treatment with L-TC and preoperative HFRT in patients who were aged 18 years or older with documented localised or locally advanced soft-tissue sarcoma of the extremity. Eligible patients will be randomly assigned 2:1 to receive a preoperative HFRT alone (Arm A) or L-TC with preoperative HFRT (Arm B).

NCT Number	NCT06476704
Lead Sponsor	Centre Paul Strauss Collaborators: LEAF4Life, Inc.
Conditions	Sarcoma
Enrollment	42 participants
Start Date	2026-07-01
Primary Completion	2028-10-15 (estimated)
Study Completion	2033-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-04