Human Research Program Flight Thigh Cuff

Venoconstrictive Thigh Cuffs (VTC) are being evaluated to determine the effectiveness at reversing the headward fluid shift that occurs during weightlessness. If successful, future studies may be done to implement these as a CM to SANS. To support this effort, participants will participate in 2 preflight study sessions consisting of a VTC fit check and a baseline data collection without and with the VTC donned. Participants will also participate in 3 inflight study sessions: a VTC fit check on flight day 30 (FD30) and two separate data collection sessions on flight day 45 (FD45) and 45 days before landing (R-45). During the two in-flight data collection days, participants will be studied before and for up to 6 hours after donning the VTC.

NCT Number	NCT06476106
Lead Sponsor	National Aeronautics and Space Administration (NASA)
Conditions	Healthy
Enrollment	10 participants
Start Date	2023-03-24
Primary Completion	2028-05-14 (estimated)
Study Completion	2030-05-14 (estimated)
Updated on ClinicalTrials.gov	2025-04-01