Evaluation of Two Methods of Administration of Photobiomodulation in the Context of the Prevention and Treatment of Mucositis Induced by Radiotherapy, During the Treatment of Head and Neck Cancers

The aim of this feasibility, prospective, single-center trial is to compare an intra-oral Photobiomodulation (PBM) via the Caremin650TM device (NeoMedLight) and a transcutaneous PBM via the ATP 38® device (Swiss Bio Innov) in patients treated with radiotherapy or chemoradiotherapy for cancer of the oropharynx or oral cavity. PBM session will be carried out first at the rate of two sessions per week for preventive purposes, and then, in case of occurence of grade 1 mucositis, three sessions per week with curative purpose.

NCT Number	NCT06458517
Lead Sponsor	Centre Paul Strauss
Conditions	Head and Neck Neoplasms
Enrollment	60 participants
Start Date	2026-06-15
Primary Completion	2029-11-15 (estimated)
Study Completion	2029-11-15 (estimated)
Updated on ClinicalTrials.gov	2026-06-05