Pulmonary Rehabilitation in the Chronically Critically Ill Patient

The goal of this observational study is to learn about the population of chronically critical ill patients who refer to respiratory rehabilitation units. The main questions it aims to answer are: * what are the clinical and pathophysiological characteristics of the population of chronically critical ill patients who refer to respiratory rehabilitation units after hospital admission with the need for prolonged invasive mechanical ventilation via tracheostomy? * what is the response of this patient population to respiratory rehabilitation treatment in terms of functional recovery, weaning from invasive mechanical ventilation, weaning from tracheostomy tube, mortality and return to home? * are there any appreciable indices at admission and/or in the first period of hospitalization which may have a prognostic significance both on short-term objectives (weaning from invasive mechanical ventilation, weaning from the tracheostomy tube) and in the medium-long term (survival, state of health)? Participants will be subjected to a rehabilitation and weaning program consisting of: * physical therapy, * speech therapy, * nutritional assessment and therapy, * in subjects on invasive mechanical ventilation at admission a program of weaning and, if needed, shift from invasive to Non-Invasive Ventilation will be performed.

NCT Number	NCT06453421
Lead Sponsor	Fondazione Don Carlo Gnocchi ETS
Conditions	Rehabilitation, Chronic Critical Illness
Enrollment	220 participants
Start Date	2023-02-10
Primary Completion	2028-01-31 (estimated)
Study Completion	2029-08-10 (estimated)
Updated on ClinicalTrials.gov	2025-03-03