Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders

The goal of this clinical trial is to study how physical exercise works when applied to patients diagnosed with Major Depressive Disorder (MDD). The main questions it aims to answer are: * What are the antiinflammatory and oxidative stress and neural mechanisms involved in the antidepressant effects of exercise? * How effective is a physical exercise program in MDD patients in real-life conditions? The experimental group will receive an exercise intervention as an add-on to their usual treatment (antidepressant treatment prescribed by the attending specialist). Researchers will compare to a control group, which will only receive standard treatment (antidepressant treatment prescribed by the attending specialist) and will be instructed to not change their usual physical activity. The aim is to see if a physical exercise intervention would induce a significant improvement in depressive symptoms and which mechanisms are responsible for this result.

NCT Number	NCT06450704
Lead Sponsor	Fundación de Investigación Biomédica - Hospital Universitario de La Princesa Collaborators: Hospital Universitario La Paz, Hospital Universitario Ramon y Cajal, Hospital Universitario Principe de Asturias, Quirón Madrid University Hospital, Universidad Autonoma de Madrid, Centro de Investigación Biomédica en Red de Salud Mental, Puerta de Hierro University Hospital
Conditions	Major Depressive Disorder, Inflammatory Response
Enrollment	124 participants
Start Date	2025-04-21
Primary Completion	2026-09-01 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-01-06