The Effect of Local and Systemic Tranexamic Acid on Edema and Ecchymosis in Orbital Surgery

Tranexamic acid (TXA) is a synthetic reversible competitive inhibitor to plasminogen lysine receptor, which prevents plasmin formation and stabilizes the fibrin matrix, thus reducing bleeding. While recent studies have demonstrated the antifibrinolytic benefits of TXA in obstetric and gynecologic conditions, traumatic hemorrhage, cardiac surgery, total knee arthroplasty, and more, there is a paucity of clinical data on TXA use in plastic surgery. The aim of this study is to evaluate the effect of local and systemic TXA on postoperative periocular ecchymosis/edema in orbital surgery.

NCT Number	NCT06450392
Lead Sponsor	Montefiore Medical Center
Conditions	Orbital Edema, Orbital Ecchymosis
Enrollment	150 participants
Start Date	2024-10-07
Primary Completion	2027-01 (estimated)
Study Completion	2027-01 (estimated)
Updated on ClinicalTrials.gov	2025-12-16