The Role of Peripheral Afferents in Modulating Post-stroke Central Pain

Central post-stroke pain (CPP) is extremely difficult to relieve and responds very poorly to analgesics targeting neuropathic pain, probably because the mechanisms underlying this pain remain poorly understood. Stroke pain is traditionally considered to be of central origin and related to changes in the spinal cord and/or brain nociceptive systems. However, a recent study in a small cohort of patients has suggested that the peripheral nervous system (PNS) may have a role in the initiation and persistence of APD. The main objective of this prospective randomised controlled bicentric study (Raymond Poincaré and Ambroise Paré) in double blind and parallel groups against placebo (3 arms) will be to evaluate the efficacy of two peripheral nerve blocks performed 14 days apart on spontaneous neuropathic pain after stroke. The active treatments used for the blocks will be either lidocaine 20 mg/ml or levobupivacaine 1.25 mg/ml or placebo (saline)

NCT Number	NCT06446960
Lead Sponsor	Institut National de la Santé Et de la Recherche Médicale, France
Conditions	Stroke
Enrollment	36 participants
Start Date	2024-02-09
Primary Completion	2026-09-08 (estimated)
Study Completion	2026-09-08 (estimated)
Updated on ClinicalTrials.gov	2026-04-22