Post-operative Radiotherapy Omission in Selected Patients With Early Breast Cancer Trial International VErsion (PROSPECTIVE)

The PROSPECTIVE trial aims to find out if using the results of Magnetic Resonance Imaging (MRI) for early breast cancer can select people to not have radiotherapy and still have a low chance of the cancer coming back after surgery. The main question it aims to answer is: \* Will cancer come back in the same breast as the original cancer in patients who have surgery for their breast cancer, but who don't have radiotherapy afterwards because the results of an MRI before surgery showed favourable characteristics for not having radiotherapy.

NCT Number	NCT06445738
Lead Sponsor	Breast Cancer Trials, Australia and New Zealand
Conditions	Breast Cancer, Breast Cancer Female
Enrollment	1,400 participants
Start Date	2025-06-06
Primary Completion	2032-06 (estimated)
Study Completion	2039-06 (estimated)
Updated on ClinicalTrials.gov	2026-01-15