Short Versus Long-term Levetiracetam in Brain Tumors

Levetiracetam is the commonly preferred anti-seizure medicine in patients with brain tumors. This drug has reduced the risk of seizure events occurring but is associated with a risk of side effects such as increased headache, drowsiness, loss of muscle coordination, and psychological challenges in patients. In patients undergoing appropriate treatment for brain tumors and controlled of seizures in the initial few months of levetiracetam, the chance of further seizures is relatively low. The optimal duration to give levetiracetam is not well defined for these patients, and currently as standard treatment levetiracetam is continued for 2-3 years. This study aims to answer this question by comparing patients on a short course of levetiracetam (experimental arm) versus a longer course of levetiracetam (standard arm), with the anticipation that a shorter duration of treatment will not lead to increased seizure episodes.

NCT Number	NCT06442748
Lead Sponsor	Tata Memorial Centre Collaborators: Manipal Academy for Higher Education
Conditions	Seizures, Brain Tumors, Antiepileptics, Levetiracetam
Enrollment	604 participants
Start Date	2024-07-04
Primary Completion	2031-06-01 (estimated)
Study Completion	2031-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-02-13