Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke

Many patients with acute ischemic stroke are ineligible for currently available standard treatments (clot-busting medication, also known as intravenous thrombolytic or mechanical removal of a clot), and many are non-responders, resulting in a low rate of excellent outcomes, which necessitates the development of novel therapies. In this study, investigators are testing a new treatment in which a weak electrical current will be applied via scalp electrodes to increase collateral blood flow to the brain and rescue the brain tissue at risk of injury. The primary aim is to find an optimal dose of this therapy that is both adequately safe and effective on imaging markers of brain tissue rescue.

NCT Number	NCT06440707
Lead Sponsor	University of California, Los Angeles Collaborators: Johns Hopkins University, Duke University, Cedars-Sinai Medical Center, University of California, San Francisco, National Institute of Neurological Disorders and Stroke (NINDS)
Conditions	Acute Ischemic Stroke
Enrollment	120 participants
Start Date	2025-07-15
Primary Completion	2030-01-01 (estimated)
Study Completion	2030-08-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-01