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Early Switch From Controlled to Assisted Ventilation

Study acronym: SWITCH-SAFE
StatusCompleted
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Trial completed Primary completion date changed from estimate of Apr 2026 to Sep 12, 2026 · Interventions: Pre-specified switch from controlled to assisted ventilation when PaO2/FiO2-ratio > 200 mmHg (Other) to Pre-specified switch from controlled to assisted ventilation when PaO2/FiO2-ratio > 200 mmHg (Other) · Eligibility criteria expanded, about 12 words · 3 more Show 6 more changesShow less
    • Primary completion date changed from estimate of Apr 2026 to Sep 12, 2026
    • Interventions: Pre-specified switch from controlled to assisted ventilation when PaO2/FiO2-ratio > 200 mmHg (Other) to Pre-specified switch from controlled to assisted ventilation when PaO2/FiO2-ratio > 200 mmHg (Other)
    • Eligibility criteria expanded, about 12 words
    • Secondary endpoints: details revised at 2 of 11 entries
    • Study description shortened, about 16 words
    • Site details revised
  2. Start date changed from estimate of Aug 2024 to Sep 15, 2024v3
  3. Trial status: Not Yet Recruiting to Recruiting Start date: May 2024 to Aug 2024 · Study sites: 0 to 1v2 Show 2 more changesShow less
    • Start date: May 2024 to Aug 2024
    • Study sites: 0 to 1
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this physiological intervention study is to unravel the (patho)physiological mechanisms and potential clinical benefits of a pre-specified early switch from controlled to assisted ventilation in mechanically ventilated adult patients with acute hypoxemic respiratory failure (PaO2/FiO2 ratio \< 200 mmHg). The intervention is that participants will be switched from controlled to assisted ventilation when PaO2/FiO2 ratio \> 200 mmHg. The primary endpoint is the change in regional lung stress (as derived by electrical impedance tomography) when switching from controlled to assisted ventilation and until a successful or failed switch.
Trial Details
NCT Number NCT06438198
Lead Sponsor Erasmus Medical Center
Conditions Acute Hypoxemic Respiratory Failure, Mechanical Ventilation
Enrollment 20 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov