Exploration of Mechanisms for Weaning Failure

This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline physiologic parameters of the patients prior to the spontaneous breathing test（SBT). The participants will be divided into a successful withdrawal group and a failed withdrawal group according to the SBT outcome, and the changes in the above parameters during SBT will be compared between the two groups .

NCT Number	NCT06424314
Lead Sponsor	The First Affiliated Hospital of Guangzhou Medical University
Conditions	Weaning Failure, Central Respiratory Depression, Diaphragm Injury, Phrenic Nerve Disorder
Enrollment	30 participants
Start Date	2024-07-09
Primary Completion	2025-07-01 (estimated)
Study Completion	2025-12-01 (estimated)
Updated on ClinicalTrials.gov	2024-07-09