Integrating MOUD in Nonmedical Community Settings (Better Together)

A multisite effectiveness-implementation study will be conducted in four sites to evaluate interventions to improve engagement and retention in MOUD with buprenorphine treatment persons with Opioid Use Disorder (OUD) in urban neighborhoods with high overdose rates. The investigators hypothesize that treatment with the Better Together Integrated Collaborative Community MOUD care model (BT-MOUD) will result in better retention in treatment than standard-of-care MOUD with buprenorphine provided in the hub buprenorphine clinic only (HC-MOUD Only) through 24 weeks following randomization. BT-MOUD provides MOUD with buprenorphine in nonmedical community-based settings via telemedicine from a hub buprenorphine clinic combined with Recovery Guiding, a manual guided coaching developed for this approach, provided onsite in the community organization.

NCT Number	NCT06416020
Lead Sponsor	Howard University Collaborators: University of Illinois at Chicago, University of Miami, National Institute on Drug Abuse (NIDA), The Emmes Company, LLC, University of Maryland
Conditions	Opioid Use Disorder
Enrollment	400 participants
Start Date	2026-01-26
Primary Completion	2028-07 (estimated)
Study Completion	2028-07 (estimated)
Updated on ClinicalTrials.gov	2025-12-03