Clinical Trial

Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder

Recruiting
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Record status
This record was last updated August 13, 2025 (before its estimated January 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
Alcohol Use Disorders are currently positioned as the third leading cause of preventable death in the United States, constituting a humanitarian crisis with substantial financial burden on society and medical facilities. While several pharmacological interventions exist, 60% of individuals who seek these treatments relapse to alcohol within 6 months. These high relapse rates are due in part to elevated brain response to alcohol cues in the environment. This study seeks to evaluate the efficacy of one session of functional Magnetic Resonance Imaging (fMRI) guided transcranial magnetic stimulation (TMS) as a strategy to reduce brain reactivity to alcohol cues.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2024-05-09; most recent amendment 2025-08-07.
Status change: Not Yet Recruiting → Recruiting 2025-07-14
Trial Details
NCT Number NCT06415721
Lead Sponsor VA Palo Alto Health Care System
Collaborators: Stanford University, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Conditions Alcohol Use Disorder, Alcohol Abuse, Alcoholism, Drinking Behavior, Drinking Problem
Enrollment 40 participants
Start Date 2025-08-25
Primary Completion 2026-01-01 (estimated)
Study Completion 2026-01-01 (estimated)
Updated on ClinicalTrials.gov 2025-08-13