Left Atrial Appendage Arrhythmogenic and Thrombogenic Substrate

The purpose of the project is to elucidate whether it is possible to identify which patients are at risk of forming blood clots that can cause stroke based on analysis of the electrocardiogram. In connection with the operation, the small pouch known as the auricle of the heart is closed, which can be completely removed after closing. This procedure is common in patients with atrial fibrillation to protect the brain from stroke. In the project, all patients will have this auricle closed if they agree to participate in the project. After closure, the auricle is usually discarded. We will analyze the blood and the auricle tissue taken (if available) in connection with the operation itself, together with the analysis of the electrocardiogram recorded before the planned heart operation.

NCT Number	NCT06405750
Lead Sponsor	University Hospital Bispebjerg and Frederiksberg Collaborators: Rigshospitalet, Denmark, University of Copenhagen
Conditions	Atrial Fibrillation, Stroke
Enrollment	1,000 participants
Start Date	2024-08-01
Primary Completion	2035-12-31 (estimated)
Study Completion	2035-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-01-15