Evaluation Contact X-ray Brachytherapy for Rectal Preservation in Intermediate Substage Rectal Adenocarcinoma

Indication : Adult patients with intermediate low or mid rectal adenocarcinoma to be treated with total neoadjuvant therapy (TNT) potentially eligible for rectal preservation. Primary objective is to assess efficacy of contact X-ray brachytherapy (CXB) in addition to TNT in order to increase survival with organ preservation (OP), in selected intermediate risk group of rectal adenocarcinomas (size from 3.1 to 6 cm, cT2N1 or T3N0-1, M0).

NCT Number	NCT06402864
Lead Sponsor	Gustave Roussy, Cancer Campus, Grand Paris
Conditions	Adult With Intermediate Low or Mid Rectal Adenocarcinoma
Enrollment	212 participants
Start Date	2024-03-26
Primary Completion	2029-06-15 (estimated)
Study Completion	2030-06-15 (estimated)
Updated on ClinicalTrials.gov	2025-12-04