Clinical Trial

Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort

Recruiting Phase 4
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Summary
Catheter-related bladder discomfort (CRBD) is common in patients awaking from general anesthesia with an urinary catheter. We suppose that that use of dexmedetomidine and/or esketamine during anesthesia may reduce the occurrence of CRBD. This 2x2 factorial randomized trial is designed to explore the effects of esketamine, dexmedetomidine, and their combination on the occurrence CRBD in patients undergoing transurethral urological surgery.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2024-05-01; most recent amendment 2025-07-28.
Status change: Not Yet Recruiting → Recruiting 2024-06-06
Trial Details
NCT Number NCT06399185
Lead Sponsor Peking University First Hospital
Collaborators: Peking University Shenzhen Hospital
Conditions Urinary Catheter, Catheter-related Bladder Discomfort, Dexmedetomidine, Esketamine
Enrollment 1,740 participants
Start Date 2024-06-06
Primary Completion 2027-04 (estimated)
Study Completion 2027-05 (estimated)
Updated on ClinicalTrials.gov 2025-07-31