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PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial

Study acronym: POPCORN
StatusRecruiting
PhaseNot applicable
Started2025-04-30
View on ClinicalTrials.gov ↗

Amendment history

2026-05-28
Study Status, Contacts/Locations v8
Study sitescontacts updated at 1 of 2 sites
2025-06-24
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v7
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2025-06→confirmed 2025-04-30
Study sitesdetails revised at 2 of 2 sites
2025-03-19
Study Status v6
Primary completion date2028-05→2028-09
Completion date2029-02→2029-06
Start date2025-02→2025-06
2024-12-18
Study Status v5
Primary completion date2027-02→2028-05
Completion date2028-11→2029-02
Start date2024-11→2025-02
2024-10-17
Study Status v4
Primary completion date2026-12→2027-02
Completion date2028-09→2028-11
Start date2024-09→2024-11
Show 3 earlier versions
2024-09-13
Study Status v3
Primary completion date2026-11→2026-12
Completion date2028-08→2028-09
Start date2024-08→2024-09
2024-06-24
Study Status, Contacts/Locations v2
Primary completion date2026-09→2026-11
Completion date2028-06→2028-08
Start date2024-06→2024-08
Study sitescontacts updated at 1 of 2 sites
2024-05-03
Study Status, Outcome Measures v1
Secondary endpoints5 entries, revised
Treatment-related adverse events (AEs) assessed by Common Terminology Criteria for Adverse Events version 5.0 (CTCAE v5.0) Grade 3 central nervous system (CNS) toxicities assessed by CTCAE v5.0 Assessment of symptoms using the MD Anderson Symptom Inventory for Brain Tumors (MDASI-BT) Quality of life (QOL) assessed by the EuroQOL 5-dimension, 5-level (EQ-5D-5L)
2024-04-30
Original filing
The purpose of this research study is to see if a specific type of radiation therapy, called "proton pulsed reduced dose rate" or "PRDR radiotherapy" has any benefits at dose levels and number of fractions thought to be acceptable in earlier research studies. The researchers want to find out what effects (good and bad) PRDR has on people with cancer in the brain called a "recurrent high-grade glioma" meaning that it grows fast, can spread quickly, and it has come back or gotten worse after being treated previously.
Trial Details
NCT Number NCT06397560
Lead Sponsor Baptist Health South Florida
Collaborators: Ion Beam Applications
Conditions Glioma, Glioma, Malignant, Recurrent Glioma
Enrollment 28 participants
Start Date 2025-04-30
Primary Completion 2028-09 (estimated)
Study Completion 2029-06 (estimated)
Updated on ClinicalTrials.gov 2026-06-01