Efficacy, Safety, and Acceptability of Mifepristone 50 mg Once-weekly as a Contraceptive

Participants in the study will use mifepristone 50 mg once-a-week for one year as a contraceptive. With this, we want to confirm that the chances of getting pregnant while using this contraceptive are very small. We also want to demonstrate that the use of mifepristone is safe, and it does not lead to any severe health problems. We expect fewer side effects compared to other frequently used contraceptives with hormones. Mifepristone does not contain these hormones. It is important to know how people experience that use of one tablet a week.

NCT Number	NCT06394999
Lead Sponsor	Leiden University Medical Center Collaborators: Karolinska Institutet, Women on Waves, Children's Investment Fund Foundation
Conditions	Female Contraception
Enrollment	615 participants
Start Date	2025-05-02
Primary Completion	2027-06-01 (estimated)
Study Completion	2028-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-06-08