Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients

Monitoring airway pressure is essential for patients with mechanical ventilation. However, static airway pressure does not reflect alveolar pressure at all. Airway pressure is supposed to completely interrupt the communication between proximal airway opening and the distal alveolar and/or small airway structures. In this condition, some alveoli may still be inflated but do not communicate with proximal airways and auto-PEEP will give a biased estimated of mean alveolar pressure. To be note, distinguishing the airway closure and alveolar collapse can be challenging at times. The quasi-static PV curve is a useful bedside tool to set mechanical ventilation, which may help us to identify the airway closure and alveolar collapse. Meanwhile, the quasi-static PV curve can only reflects a global behaviour of the lung, while EIT may be a useful tool to assess the regional information on airway closure and alveolar collapse.

NCT Number	NCT06393179
Lead Sponsor	Southeast University, China
Conditions	Mechanical Ventilation Pressure High, Critical Illness
Enrollment	60 participants
Start Date	2024-05-30
Primary Completion	2024-08-30 (estimated)
Study Completion	2024-08-30 (estimated)
Updated on ClinicalTrials.gov	2024-08-16