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HIT-CLLNCT06379282

Investigating the Role of Energy Balance Modification on Health Responses in Chronic Lymphocytic Leukaemia

StatusActive, Not Recruiting
PhaseNot applicable
Primary completion
Track this trial

Free. We email you which fields changed when ClinicalTrials.gov updates this record.

Record History

All 3 versions: 3 with changes below. See every version on ClinicalTrials.gov ↗

  1. Eligibility criteria expanded, about 12 words Show 4 more changesShow less
    • Primary endpoints: details revised at 1 of 2 entries
    • Trial status changed: Unknown → Active, Not Recruiting
    • Study completion pushed from Aug 1, 2026 to Aug 1, 2030
    • Site details revised
  2. Changed Registry marked status Unknown; last known: Recruiting
  3. Trial status: Recruiting to Unknown
    • Secondary endpoints revised (7)
    v2
  4. Study First Submitted
  • Notable: the plan changed
  • Minor: routine updates

Endpoints

Primary

Change from baseline in absolute number of CD19+/CD5+ CLL cells at week 12
Timeframe: Baseline and 12 weeks
Change from baseline in cardiorespiratory fitness (CRF: VO2peak) at week 12
Timeframe: Baseline and 12 weeks

Secondary (7)

Frailty
Muscle Strength and Endurance
Muscle Health
Change in Quality of Life using the EORCT-QLQ-C30
Change in muscle oxygen metabolism during a single bout of exercise
Show 2 moreShow less
Change in B-CLL Cell Function
Change in systemic and cellular bioenergetics

Arms and interventions

HIT GroupExperimental

Exercise Only * 3 sessions per week * Aerobic + Resistance Exercises

EXE+ GroupExperimental

Exercise + Nutritional Guidance * 3 sessions per week * Aerobic + Resistance Exercises * Dietary assessment at baseline and during with guidance on eating a healthy diet provided

Control GroupNo intervention

Control group will receive no exercise or nutritional guidance

Behavioral: HIT, EXE+ Nutritional Guidance

Sites

1 site in 1 country

  • University of SurreyGuildford, United Kingdom