Clinical Trial

Mechanisms of Acute Kidney Injury in Severe Infections

Study acronym: PET-AKI
Recruiting
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Record status
This record was last updated December 6, 2024 (before its estimated April 3, 2026 completion). Its status may not reflect the trial's current state.
Summary
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2024-04-15; most recent amendment 2024-12-03.
Status change: Not Yet Recruiting → Recruiting 2024-12-03
Trial Details
NCT Number NCT06372444
Lead Sponsor Uppsala University Hospital
Conditions Sepsis, AKI - Acute Kidney Injury, Positron Emission Tomography (PET)
Enrollment 15 participants
Start Date 2024-05-01
Primary Completion 2026-04-03 (estimated)
Study Completion 2026-06-30 (estimated)
Updated on ClinicalTrials.gov 2024-12-06