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Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion

StatusNot Yet Recruiting
PhaseEarly Phase 1
Started
View on ClinicalTrials.gov ↗

Record History

  1. Primary and study completion dates: Sep 2027 to Sep 2028
    • Start date: Dec 2025 to Dec 2027
    v4
  2. Re-verified, no change to tracked fieldsv3
  3. Primary and study completion dates: Sep 2025 to Sep 2027
    • Start date: Sep 2024 to Dec 2025
    v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
In this study, we are trying to see if vitamin B6 can minimize the amplified blood pressure response to exercise following ischemia-reperfusion injury. We are interested in a protein called P2X3, of which function can be blocked by vitamin B6, in the neurons of our nervous system. It is very important for blood pressure regulation. We would like to see if the P2X3 plays a role in patients' rising blood pressure during exercise. The results of the proposed studies will provide a base for those two potential economic and non-invasive inventions to improve the overall health and well-being of PAD patients.
Trial Details
NCT Number NCT06369350
Lead Sponsor Milton S. Hershey Medical Center
Collaborators: American Heart Association
Conditions
(from sponsor)		 Ischemia Reperfusion Injury, Peripheral Artery Disease
Related terms Peripheral Arterial Disease, Reperfusion Injury
Enrollment 30 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov