Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine

This is a clinical investigation to measure the changes in the oral environment resulting from a 3 month exposure to an arginine containing toothpaste. This study is a double blind, randomized controlled, parallel design. Seventy (70) male and female subjects who meet the inclusion/exclusion criteria will be enrolled in the study. Following oral health evaluations, subjects will be assigned to the treatment schedule and receive their assigned study product.

NCT Number	NCT06365047
Lead Sponsor	Tufts University Collaborators: Colgate Palmolive
Conditions	Xerostomia
Enrollment	70 participants
Start Date	2024-08-31
Primary Completion	2027-12-01 (estimated)
Study Completion	2028-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-02-10