Clinical Trial

Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections

Recruiting Phase 3
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Summary
This is a multicenter randomized controlled trial of 1100 patients to evaluate the superiority of combined intraoperative wound irrigation with intraoperative peritoneal lavage with dilute aqueous povidone-iodine compared to normal saline in male and female patients between the ages of 18 and 80 years old undergoing emergency laparotomies with Centers for Disease Control (CDC) class 2 and 3 wounds.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2024-04-09; most recent amendment 2025-11-17.
Status change: Not Yet Recruiting → Recruiting 2024-10-15
Trial Details
NCT Number NCT06363877
Lead Sponsor Loma Linda University
Conditions Surgical Site Infection
Enrollment 1,100 participants
Start Date 2024-06-03
Primary Completion 2026-10 (estimated)
Study Completion 2026-11 (estimated)
Updated on ClinicalTrials.gov 2025-11-19