Improving the Success Rate for Thoracic Radiotherapy Through Specific Cardiac Substructure Dosimetry: Location Matters. (LOCATION MATTERS)

The prospective study LOCATION MATTERS aims to investigate the radiation-induced damage to the heart and the cardiovascular system in patients treated with thoracic radiotherapy. Patients enrolled in the study will complete a set of extensive measures at the baseline, end of RT, and 9 months after treatment. Ultrasound exams, CT scans, pulmonary tests and wearable devices will assess functional and morphological parameters and the association with their variation and the dose delivered to the heart substructures and to the normal lung.

NCT Number	NCT06361784
Lead Sponsor	Fondazione IRCCS Istituto Nazionale dei Tumori, Milano Collaborators: Politecnico di Milano
Conditions	Locally Advanced Lung Non-Small Cell Carcinoma
Enrollment	150 participants
Start Date	2024-03-29
Primary Completion	2029-03-29 (estimated)
Study Completion	2029-03-29 (estimated)
Updated on ClinicalTrials.gov	2024-04-15