Clinical Trial

Methylprednisolone Adjunctive to Endovascular Thrombectomy for Stroke

Study acronym: MIRACLE
Active, Not Recruiting Phase 3
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Summary
The efficacy and safety of methylprednisolone in acute ischemic stroke patients with large infarct cores (ASPECTS score \< 6 or infarct volume ≥50 mL) due to anterior circulation large vessel occlusion have not been clearly established. This is a multi-center, randomized, double-blind, placebo-controlled trial to investigate early combination therapy with methylprednisolone for reperfusion in acute large core infarction.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2024-04-07; most recent amendment 2025-11-25.
Status change: Recruiting → Active, Not Recruiting 2025-07-14
Status change: Not Yet Recruiting → Recruiting 2024-09-16
Trial Details
NCT Number NCT06360458
Lead Sponsor Wan-Jin Chen
Conditions Acute Ischemic Stroke, Large Infarct Core
Enrollment 928 participants
Start Date 2024-08-01
Primary Completion 2025-09-30 (estimated)
Study Completion 2030-06-30 (estimated)
Updated on ClinicalTrials.gov 2025-12-03