Clinical Trial

Effects of Tuberculosis Infection on Development and Function of the Placenta

Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated March 17, 2025 (before its estimated March 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on the placenta. The main questions it aims to answer are: * Does TB infection affect the structure of the placenta? * Does TB infection affect the function of the placenta? Pregnant women attending delivery clinics in Addis Abeba, Ethiopia, will be enrolled and classified for TB infection using a blood-based test. We will compare the following outcomes between women with TB infection and women without TB infection: * Pathological lesions of the placenta * Gene and protein expression patterns linked to pregnancy-related disorders * Infant outcome at birth and at 6 weeks after birth
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2024-04-03; most recent amendment 2025-03-14.
Status change: Not Yet Recruiting → Recruiting 2025-03-14
Trial Details
NCT Number NCT06352970
Lead Sponsor Lund University
Collaborators: Addis Ababa University, Armauer Hansen Research Institute, Ethiopia
Conditions Pregnancy Related, Tuberculosis Infection, Placenta Diseases
Enrollment 500 participants
Start Date 2024-10-01
Primary Completion 2026-03-31 (estimated)
Study Completion 2027-12-31 (estimated)
Updated on ClinicalTrials.gov 2025-03-17