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Early and Late Effects of Nefopam in Multimodal Analgesia After Total Hip Arthroplasty (NEFARTHRO)

Name: Early and Late Effects of Nefopam in Multimodal Analgesia After Total Hip Arthroplasty (NEFARTHRO) — clinical trial record (NCT06349798)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: NEFARTHRO

StatusNot Yet Recruiting

PhasePhase 3

SponsorUniversity Hospital, Tours

Started2024-04

View on ClinicalTrials.gov ↗

Record status

This record was last updated April 5, 2024 (before its estimated September 2026 completion). Its status may not reflect the trial's current state.

University Hospital, Tours

120 trials monitored

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NEFARTHRO is a multicentric randomized controlled trial comparing the effects of discontinuous infusions of nefopam (bolus) versus continuous infusion of intravenous nefopam (via an infusion pump) versus placebo on the opioid-request during the first 24 hours following a Total Hip arthroplasty, as part of multimodal analgesia including at least paracetamol and a Non-Steroidal Anti-Inflammatory Drug (NSAID). The primary endpoint is cumulative morphine consumption for the first postoperative 24 hours, expressed in mg of iv equivalent morphine, including titration in the Post Anesthesia Care Unit (PACU). Patients will be followed during 6 months.

Trial Details

NCT Number	NCT06349798
Lead Sponsor	University Hospital, Tours
Conditions	Total Hip Arthroplasty
Enrollment	546 participants
Start Date	2024-04
Primary Completion	2026-09 (estimated)
Study Completion	2027-04 (estimated)
Updated on ClinicalTrials.gov	2024-04-05