Estradiol and Testosterone Subdermal Implants for Menopause Treatment (ESTIME)

Estrogen and androgen deficiencies negatively impact the quality of life of women at different stages of life, especially after menopause. New modalities and new therapeutic alternatives have been researched. Parenteral administration of estradiol and testosterone could be effective to treat symptoms secondary to estrogen and androgen deficiencies and minimize these adverse events. This study evaluates the efficiency of subdermal implant-bioabsorbable use in women with menopausal symptoms associated with secondary estrogen and androgen deficiencies in women with natural menopause, premature ovarian failure or surgical menopause due to cervical cancer. Pharmacokinetic, biochemical, metabolic, thromboembolic and hormonal data will be evaluated, as well as the effects on quality of life, menopausal symptoms and sexual function after treatment.

NCT Number	NCT06343870
Lead Sponsor	University of Sao Paulo General Hospital
Conditions	Menopause, Testosterone Deficiency, Estrogen Deficiency
Enrollment	140 participants
Start Date	2025-12-18
Primary Completion	2026-08-18 (estimated)
Study Completion	2027-04-30 (estimated)
Updated on ClinicalTrials.gov	2025-12-29